Primary Information |
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| BoMiProt ID | Bomi10213 |
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| Protein Name | Ubiquitin carboxyl-terminal hydrolase 1/Deubiquitinating enzyme 1//Ubiquitin thioesterase 1/Ubiquitin-specific-processing protease 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RP1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039689.1 |
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| Aminoacid Length | 783 |
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| Molecular Weight | 88459 |
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| FASTA Sequence |
Download |
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| Gene Name | USP1 |
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| Gene ID | 516328 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | USP1 regulates PI3K‐Akt‐FoxO and mTOR signalling in the muscle during prolonged starvation to maintain homeostasis under low energy conditions.It removes K63‐linked and K8 linked polyubiquitin chains from AKT. |
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| Biochemical Properties | cysteine proteases,which process ubiquitin chains to reverse protein modification by ubiquitination.Contains a catalytic core composed of conserved N‐terminal Cys box motif and C‐terminal His box motif. |
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| PTMs | phosphorylation,Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q29RP1|UBP1_BOVIN Ubiquitin carboxyl-terminal hydrolase 1 OS=Bos taurus OX=9913 GN=USP1 PE=2 SV=1
MPGVIPSESNGLSRGS*16PSKKNRLSLKFFQKKETKRALDFTDS*42QENEEKTSEYKGSEIDQV
VPAAQSS*67PINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVEDLSTKVEEYQKEE
MSDNNSMEMDNMRHSEDYKEKLSKGNGKRKSDAEFGNMKKKVKISKEHQSSEENQRQTRS
KRKAAGDTLEISHKIIPKHISENESTRPSQRKSKVKINWLKSAAKQPSILSKFCSMGKIA
TNQGSKGHCKENEYDLEEDLGKYENDNTTNDCELESPGNNDMPVHVNEVKPINKGAEQIG
FELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEENSEIS*473PEPKTEM
KTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEF
DCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTD
LNSLELDKENFVIDQTCEIGKPEPLNEEEVRGVVENYDNEEVSIRVSGNNQPSKVLNKKN
VEAIGLLGGQKSKADYELYNKASNPDKVASTALPENRNSETNNTNGTDESDSNKESSDQT
GINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLS*766PSTSPTSTPYLLFY
KKL
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| Predicted Disorder Regions | 9-57, 242-244, 261-282, 305-362, 383-394, 409-415, 620-713 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation is related to its inhibition.autocleavage at an internal diglycine motif (Gly670‐Gly671) that promotes USP1 degradation by the proteasome. |
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| Additional Comments | USP1 levels are elevated in several human cancers |
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| Bibliography | Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. EMBO Rep. 2020 Apr 3;21(4):e48791. doi: 10.15252/embr.201948791. Epub 2020 Mar 5. PMID: 32133736; PMCID: PMC7132338. |
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