Primary Information |
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| BoMiProt ID | Bomi10214 |
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| Protein Name | Ubiquitin carboxyl-terminal hydrolase 13 |
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| Organism | Bos taurus |
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| Uniprot ID | E1BMF7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001178195.1 |
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| Aminoacid Length | 863 |
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| Molecular Weight | 97278 |
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| FASTA Sequence |
Download |
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| Gene Name | USP13 |
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| Gene ID | 100141289 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | negatively regulates antiviral responses by deubiquitnitaing STING.Also deubiquitinates USP10, an essential regulator of p53/TP53 stability.USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation |
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| Biochemical Properties | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin. |
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| PTMs | Isopeptide bond, Phosphorylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BMF7|UBP13_BOVIN Ubiquitin carboxyl-terminal hydrolase 13 OS=Bos taurus OX=9913 GN=USP13 PE=3 SV=2
MQRRGALFGMPGGSGSRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEG
GLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVREKVRGASGGALPKRRNS*114KMFLDL
DT*122DDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPD
TWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSG
GNGHALEHYRDTGYPLAVKLGTITPDGADVYSFQEEEAVLDPHLAKHLAHFGIDMLHMHG
TENGLQDNDIKPRVSEWEVIQETGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEF
QRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQ
QNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEER
IQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAESNRRPLPELVRAKIP
FSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFD
VSVDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMTQLIDPSDIDESSVMQ
LAEMGFPLEACRKAVYFTGNMGAEVAFNWIVVHMEEPDFAEPLTMPGYGGAASAGASVFG
ATGLDNQPPEETVAIITSMGFHRNQAIQALRATNSNLERALDWIFSHPEFEEDSDFVIEM
ENNANANIVSEAKPEGPRVKDGSGMYELFAFISHMGTSTMSGHYVCHIKKEGRWVIYNDH
KVCASERPPKDLGYMYFYRRIPS
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| Predicted Disorder Regions | 95-109, 623-626, 648-652, 702-728, 773-800 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Man X, Piao C, Lin X, Kong C, Cui X, Jiang Y. USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer. J Exp Clin Cancer Res. 2019 Jun 14;38(1):259. doi: 10.1186/s13046-019-1262-4. Erratum in: J Exp Clin Cancer Res. 2021 Dec 9;40(1):386. PMID: 31200745; PMCID: PMC6570860. |
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