Primary Information |
|---|
| BoMiProt ID | Bomi10265 |
|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 S/E2 ubiquitin-conjugating enzyme S
Ubiquitin carrier protein S/Ubiquitin-protein ligase S |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q1RML1 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001069940.1 |
|---|
| Aminoacid Length | 223 |
|---|
| Molecular Weight | 23896 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | UBE2S |
|---|
| Gene ID | 617703 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. |
|---|
| PTMs | Phosphorylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1RML1|UBE2S_BOVIN Ubiquitin-conjugating enzyme E2 S OS=Bos taurus OX=9913 GN=UBE2S PE=2 SV=2
MNSNVENLPPHIIRLVYKEVTTLTADPPDGIKVFPNEEDLTDLQVTIEGPEGTPYAGGLF
RMKLLLGKDFPASPPKGYFLTKIFHPNVGANGEICVNVLKRDWTAELGIRHVLLTIKCLL
IHPNPESALNEEAGRLLLENYEEYAARARLLTEIHGGAGGPSGGRPEPGRATAS*174GAAAST
ADPTAPGGPAGAEGPMAKKHAGERDKKLAAKKKTDKKRALRRL
|
|---|
| Predicted Disorder Regions | (1-9), (155-223) |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | no TM helices |
|---|
| Bibliography | Chang, T. L., Kakhniashvili, D. G., & Goodman, S. R. (2005). Spectrin's E2/E3 ubiquitin conjugating/ligating activity is diminished in sickle cells. American journal of hematology, 79(2), 89–96. https://doi.org/10.1002/ajh.20351 |
|---|
