Primary Information |
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| BoMiProt ID | Bomi10473 |
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| Protein Name | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2/3-hydroxyacyl-CoA dehydratase 2/Protein-tyrosine phosphatase-like member B |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KIP8 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001124229.1 |
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| Aminoacid Length | 254 |
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| Molecular Weight | 28422 |
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| FASTA Sequence |
Download |
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| Gene Name | HACD2/PTPLB |
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| Gene ID | 613886 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. |
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| PTMs | Acetylation, Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KIP8|HACD2_BOVIN Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Bos taurus OX=9913 GN=HACD2 PE=2 SV=2
MAAAAAIAASKGNGGGGGRAGAGEASSSRRKKGPGPLTTAYLVIYNVVMTAGWLVIAVGL
VRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIVPSSVVLTSIQVMSRVFLIWA
VTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGV
SGELLTIYAALPFVRQAGLYSISLPNKYN*209FSFDYYAFLILIMISYIPLFPQLYFHMIHQR
RKILSHTEEHKKFE
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| Predicted Disorder Regions | 1-33, 250-253 |
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| DisProt Annotation | |
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| TM Helix Prediction | 4TMHs; (39-61), (84-106), (171-193), (212-234) |
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| Bibliography | Wang, B., Pelletier, J., Massaad, M. J., Herscovics, A., & Shore, G. C. (2004). The yeast split-ubiquitin membrane protein two-hybrid screen identifies BAP31 as a regulator of the turnover of endoplasmic reticulum-associated protein tyrosine phosphatase-like B. Molecular and cellular biology, 24(7), 2767–2778. https://doi.org/10.1128/MCB.24.7.2767-2778.2004 |
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