Primary Information |
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| BoMiProt ID | Bomi10782 |
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| Protein Name | Zinc finger protein 750 |
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| Organism | Bos taurus |
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| Uniprot ID | A2VDR9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001075002.1 |
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| Aminoacid Length | 703 |
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| Molecular Weight | 75167 |
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| FASTA Sequence |
Download |
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| Gene Name | ZNF750 |
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| Gene ID | 535628 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A transcription factor regulated by p63,plays a critical role in epithelial tissues homoeostasis |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 86-101, 410-421, 456-462, 495-524, 549-649 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | upregulation of ZNF750 inhibited the expression of b-catenin and the downstream targets (cyclin D1, c-Myc, Bcl-2, MMP2 and MMP9), indicating it could block the activation of Wnt/b-catenin pathway. |
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| Bibliography | Butera A, Cassandri M, Rugolo F, Agostini M, Melino G. The ZNF750-RAC1 axis as potential prognostic factor for breast cancer. Cell Death Discov. 2020 Nov 29;6(1):135. doi: 10.1038/s41420-020-00371-2. PMID: 33298895; PMCID: PMC7701147. |
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