Primary Information |
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| BoMiProt ID | Bomi3454 |
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| Protein Name | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha/1-acylglycerol-3-phosphate O-acyltransferase 1/1-AGP acyltransferase 1/1-AGPAT 1/Lysophosphatidic acid acyltransferase alpha(LPAAT-alpha) |
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| Organism | Bos taurus |
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| Uniprot ID | Q95JH2 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_803484.1 |
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| Aminoacid Length | 287 |
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| Molecular Weight | 32005 |
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| FASTA Sequence |
Download |
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| Gene Name | AGPAT1 |
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| Gene ID | 282137 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1 predicted disordered segment; (269-287) |
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| DisProt Annotation | |
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| TM Helix Prediction | 3 TMHs;(3-25),(40-58) & (129-147) |
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| Additional Comments | small interference RNA-mediated knockdown of AGPAT1 expression prevents the induction of myogenin, a key transcriptional activator of the myogenic program, and inhibits the expression of myosin heavy chain. This effect is rescued by transfection with AGPAT1 but not AGPAT2. |
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| Bibliography | Subauste AR, Elliott B, Das AK, Burant CF. A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. Differentiation. 2010 Sep-Oct;80(2-3):140-6. doi: 10.1016/j.diff.2010.05.006. Epub 2010 Jun 19. PMID: 20561744; PMCID: PMC3449212. |
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