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Primary Information | |
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| BoMiProt ID | Bomi3731 |
| Protein Name | ADP/ATP translocase 1/ADP,ATP carrier protein 1/Adenine nucleotide translocator 1/Solute carrier family 25 member 4 |
| Organism | Bos taurus |
| Uniprot ID | P02722 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_777083.1 |
| Aminoacid Length | 298 |
| Molecular Weight | 32967 |
| FASTA Sequence | Download |
| Gene Name | SLC25A4 |
| Gene ID | 282478 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Presence in other biological fluids/tissue/cells | heart, skeletal muscle, brain |
| Protein Function | The mitochondrial ADP/ATP carrier (Adenine Nucleotide Carrier or Ancp or ANC) is a nuclear encoded protein, which catalyzes the exchange of ATP4− generated in mitochondria by the ATP synthase with ADP3 produced in the cytosol by most of the energy-consuming reactions. |
| PTMs | Acetylation, Methylation, Phosphorylation at Serine, S-nitrosylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P02722|ADT1_BOVIN ADP/ATP translocase 1 OS=Bos taurus OX=9913 GN=SLC25A4 PE=1 SV=3 MSDQALS*7FLKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDRHKQFWRYFAGNLASG GAAGATSLCFVYPLDFARTRLAADVGKGAAQREFTGLGNCITKIFKSDGLRGLYQGFNVS VQGIIIYRAAYFGVYDTAKGMLPDPKNVHIIVSWMIAQTVTAVAGLVSYPFDTVRRRMMM QSGRKGADIMYTGTVDCWRKIAKDEGPKAFFKGAWSNVLRGMGGAFVLVLYDEIKKFV |
| SCOP | Class : All alpha proteins Fold : Mitochondrial carrier Superfamily : Mitochondrial carrier Family : Mitochondrial carrier Domain Name : 1OKC A:2-293 |
| CATH | Matched CATH superfamily 1.50.40.10 |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 2TMHs; (112-134),(209-231) |
| Significance of PTMs | The phosphorylation of Tyr194 by the kinase Src would be essential to the ADP/ATP transport by ANC1. |
| PDB ID | 1OKC, 2C3E, |
| Bibliography | 1.Clémençon B, Babot M, Trézéguet V. The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction. Mol Aspects Med. 2013 Apr-Jun;34(2-3):485-93. doi:10.1016/j.mam.2012.05.006. PMID: 23506884. 2.J. Feng, E. Lucchinetti, G. Enkavi, Y. Wang, P. Gehrig, B. Roschitzki, M.C. Schaub, E. Tajkhorshid, K. Zaugg, M. Zaugg.Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria.Am. J. Physiol. Cell. Physiol., 298 (2010), pp. 740-748. |