Primary Information |
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| BoMiProt ID | Bomi3820 |
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| Protein Name | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A/N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase Iva/UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase Iva |
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| Organism | Bos taurus |
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| Uniprot ID | O77836 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_803486.1 |
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| Aminoacid Length | 535 |
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| Molecular Weight | 61618 |
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| FASTA Sequence |
Download |
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| Gene Name | MGAT4A |
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| Gene ID | 282276 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Glycosyltransferase that participates in the transfer of N-acetylglucosamine to the core mannose residues of N-linked glycans.Regulating the formation of tri- and multiantennary branching structures on membrane proteins that require glycosylation as signal for its exportation in the Golgi apparatus.Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. |
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| PTMs | Glycosylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|O77836|MGT4A_BOVIN Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A OS=Bos taurus OX=9913 GN=MGAT4A PE=1 SV=1
MRLRNGTVATVLAFITSFLTLSWYTTWQNGKEKVIAYQREFLALKERLRIAEHRISQRSS
ELSAIVQQFKRVEAETN*77RSKDPVNKFSDDTLKILKELTSKKSLQVPSIYYHLPHLLQNEG
SLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGET
DTDYVNGVVANLEKEFSKEISSGLVEIISPPESYYPDLTNLKETFGDSKERVRWRTKQNL
DYCFLMMYAQEKGTYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMF
QAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQ
HVGLHSSLTGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWA
ITPVAGDYILFKFDKPVNVESYLFHSGNQDHPGDILLN*458TTVEVLPLKSEGLDIS*474KETKDK
RLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKVTN
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-25) |
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| Additional Comments | MGAT4A was identified as a genetic marker for pancreatic cancer in addition to its known role in choriocarcinoma development |
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| Bibliography | 1.López-Orduña E, Cruz M, García-Mena J. The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients. BMC Genet. 2007 Oct 22;8:73. doi: 10.1186/1471-2156-8-73. PMID: 17953760; PMCID: PMC2148049. |
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