Primary Information |
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| BoMiProt ID | Bomi4388 |
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| Protein Name | Cadherin-13 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3B7N0 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 713 |
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| Molecular Weight | 78197 |
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| FASTA Sequence |
Download |
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| Gene Name | CDH13 |
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| Gene ID | 512302 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | calcium-dependent cell adhesion proteins.imp for cell to cell attachment and communication |
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| Biochemical Properties | It lacks both transmembrane and cytoplasmic domains and is linked to the plasma membrane via a glycosylphosphatidylinositol moiety. |
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| PTMs | Cleavage on pair of basic residues, Glycosylation, GPI-anchor, Lipoprotein |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3B7N0|CAD13_BOVIN Cadherin-13 OS=Bos taurus OX=9913 GN=CDH13 PE=2 SV=1
MQPATPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHIDQPAEFIEDQAILN*52LTFSDCKG
NDKLHYEVSSPYFRVNTDGSLVALRN*86ITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGV
DQEPKGIFRINENTGSVSVTRNLDRETIATYQLFVETVDVNGRTLEGPVPLEVIVIDQND
NRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY
IDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHS
PKFTKKEFQATVEEGAMGVIVN*382LTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTN
EGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGSSSTATVHITVLDANESPVFYPD
PMMVTKQEN*489ISVGSVLLTVN*500ATDPDSLQRQTIRYSVYKDPAGWLNINPIN*530GTVDTTALLD
RESPFVHNSVYTALFLATDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKN*598LS
VVILGATDKDLHPNTDPFKFEIHKQTVPDKVWKISKIN*638NTHALVSLLQNLNKANYHLPIM
VTDSGKPPMTN*671ITDLRVQVCSCKNSKVDCNAAGAPHFSAATALLLSLFSLARL
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | CDH13 has been associated with the risk for attention-deficit/hyperactivity disorder (ADHD) and frequent comorbid conditions including drug and alcohol abuse |
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| Bibliography | Rivero, O., Selten, M., Sich, S. et al. Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition. Transl Psychiatry 5, e655 (2015). https://doi.org/10.1038/tp.2015.152 |
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