Primary Information |
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| BoMiProt ID | Bomi5303 |
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| Protein Name | Dynactin subunit 3 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P5A1 |
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| Milk Fraction | Exosomes |
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| Ref Sequence ID | NP_001069128.1 |
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| Aminoacid Length | 186 |
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| Molecular Weight | 21192 |
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| FASTA Sequence |
Download |
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| Gene Name | DCTN3 |
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| Gene ID | 514327 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | retina |
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| Protein Function | DNC-3 is a core component of dynactin and it physically interacted with DNC-1 and DNC-2 and significantly enhanced the binding ability between DNC-1 and DNC-2 in vitro. |
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| Biochemical Properties | Dynactin is a large protein complex comprised of 11 different polypeptide subunits: p150Glued (DCTN1), p50 (DCTN2), p24 (DCTN3), p62 (DCTN4), p25 (DCTN5), p27 (DCTN6), actin-related protein (ARP) 1/11, actin, and actin capping protein (CapZ) α and β. |
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| PTMs | N-acetylation at Alanine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 1-43, 47-59, 183-185 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Terasawa M, Toya M, Motegi F, Mana M, Nakamura K, Sugimoto A. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Genes Cells. 2010 Nov;15(11):1145-57. doi: 10.1111/j.1365-2443.2010.01451.x. Epub 2010 Oct 21. PMID: 20964796; PMCID: PMC3036819. 2. |
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