Primary Information |
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| BoMiProt ID | Bomi5508 |
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| Protein Name | Endothelin-1 |
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| Organism | Bos taurus |
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| Uniprot ID | P17322 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_851353.1 |
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| Aminoacid Length | 202 |
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| Molecular Weight | 22977 |
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| FASTA Sequence |
Download |
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| Gene Name | EDN1 |
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| Gene ID | 281137 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Endothelin-1 plays an important role in the pathogenesis of immune-mediated CNS demyelinating diseases by promoting immune responses.ET-1-mediated cellular functions play a critical role in normal pregnancy, preterm birth and uterine leiomyoma. |
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| Biochemical Properties | The C-terminal hydrophobic conserved sequence of ET binds to the ET receptors and the N-terminal variable region determines the binding affinity to the receptors. |
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| Significance in milk | may play a paracrine regulatory role in bovine luteal function and propose a novel role for this peptide in mediating PGF2alpha-induced luteal regression. |
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| PTMs | Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 24-47, 98-102, 134-158, 186-188, 192-202 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Proteolytically cleavage by caspases upon induction of apoptosis by TNF. |
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| Additional Comments | Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression |
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| Bibliography | 1.Tanfin Z, Leiber D, Robin P, Oyeniran C, Breuiller-Fouché M. Endothelin-1: physiological and pathological roles in myometrium. Int J Biochem Cell Biol. 2011 Mar;43(3):299-302. doi: 10.1016/j.biocel.2010.10.009. Epub 2010 Oct 23. PMID: 20974279. 2.Jin YH, Kang B, Kang HS, Koh CS, Kim BS. Endothelin-1 contributes to the development of virus-induced demyelinating disease. J Neuroinflammation. 2020 Oct 17;17(1):307. doi: 10.1186/s12974-020-01986-z. PMID: 33069239; PMCID: PMC7568825. 3.Raina R, Chauvin A, Vajapey R, Khare A, Krishnappa V. Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease
. Clin Nephrol. 2019 Jun;91(6):370-379. doi: 10.5414/CN109598. PMID: 30990410. |
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