Primary Information |
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| BoMiProt ID | Bomi5766 |
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| Protein Name | Fez family zinc finger protein 2/Forebrain embryonic zinc finger-like protein 2/Zinc finger protein 312/Zinc finger protein Fez-like |
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| Organism | Bos taurus |
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| Uniprot ID | Q2VWH6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001033287.1 |
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| Aminoacid Length | 458 |
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| Molecular Weight | 48842 |
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| FASTA Sequence |
Download |
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| Gene Name | FEZF2/ZNF312/FEZL |
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| Gene ID | 613683 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | Brain and mammary gland |
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| Protein Function | Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons |
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| Significance in milk | controls the development of monoaminergic neuron.Bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-26, 40-62,103-117, 265-269 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | FEZL-deficient mice display hyperactive behavior, suggesting that FEZL has a role in neuronal development |
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| Bibliography | 1.Sugimoto M, Fujikawa A, Womack JE, Sugimoto Y. Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6454-9. doi: 10.1073/pnas.0601015103. Epub 2006 Apr 12. PMID: 16611727; PMCID: PMC1458905. 2.Sugimoto, M., Fujikawa, A., Womack, J. E., & Sugimoto, Y. (2006). Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance. Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6454–6459. https://doi.org/10.1073/pnas.0601015103 |
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