Primary Information |
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| BoMiProt ID | Bomi6056 |
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| Protein Name | Glycerate kinase |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJF7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039452.1 |
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| Aminoacid Length | 523 |
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| Molecular Weight | 54720 |
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| FASTA Sequence |
Download |
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| Gene Name | GLYCTK |
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| Gene ID | 507949 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Take part in Entner-Doudoroff (ED) pathway.This protein phosphorylates (R)-glycerate utilising an ATP molecule to yield (2R)-3-phosphoglycerate and an ADP molecule. |
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| Biochemical Properties | Glycerate is phosphorylated via glycerate kinase, the key enzyme of the npED branch, forming 2-phosphoglycerate.(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H+. 3 classes of glycerate kinase-(i) class I (GK I), ii) the glycerate kinase class II (GK II, MOFRL family) as well as iii) a novel glycerate kinase family related to the phosphoribulokinase/uridine kinase family,named glycerate kinase class III (GK III). |
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| PTMs | Acetylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KJF7|GLCTK_BOVIN Glycerate kinase OS=Bos taurus OX=9913 GN=GLYCTK PE=2 SV=1
MAAALQVLRHLARAPSGPLLWGGPLARMASSMALAEQARQLFESTVGAVLPGPLLQRALS*60
LDPDSGELKVRDRSFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAM
EHAGKQEMLLKPHSRIQVFEGAEDNLPDRDALRAALAIRQLAEGLTADDLLLVLISGGGS
ALLPAPIPPVTLEEKQTLTKLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLI
LSDVVGDPVEVIASGPTVASIHSVQDCLYILNRYGLRTALPRSVKTVLARADSDPHGPHT
CGHVLNVILGSNALALAEAQKQAEALGYRAVVLSTAIQGDVKSVAQFYGLLARVAGAHLA
LPGAGASVQEDERLYELAADLQLPDLQLKEALEAVVGAPGPVCLLAGGEPTVRLQGSGKG
GRNQELALRVGVELGQWPLGTVDVLFLSGGTDGQDGPTEAAGAWVRPELTSQAAAEGLDV
ATFLAHNDSHTFFCRFQGGAHLLHTGLTGTNVTDAHFLFLHPQ |
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| Predicted Disorder Regions | (454-468) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Sass, J. O., Fischer, K., Wang, R., Christensen, E., Scholl-Bürgi, S., Chang, R., Kapelari, K., & Walter, M. (2010). D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK). Human mutation, 31(12), 1280–1285. https://doi.org/10.1002/humu.21375 |
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