Primary Information |
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| BoMiProt ID | Bomi6317 |
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| Protein Name | Homeobox protein PKNOX1/PBX/knotted homeobox 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2HJ84 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039815.1 |
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| Aminoacid Length | 436 |
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| Molecular Weight | 47204 |
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| FASTA Sequence |
Download |
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| Gene Name | PKNOX1/PREP1 |
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| Gene ID | 533382 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | PKNOX1 exerts tumor suppressive activity.The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression. |
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| PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2HJ84|PKNX1_BOVIN Homeobox protein PKNOX1 OS=Bos taurus OX=9913 GN=PKNOX1 PE=2 SV=1
MMATQTLSIDSYPDGQQMQVVTELKTEQDPNCS*33EPDVEGVS*41PPPVGSQTPMDADKQAIYR
HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK
AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI
TGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQ
LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN
LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGAAQPAAS
ELTVSEGAVVTITAPVSMNVDSLQSLSSDGATLAVQQVMMAEQSEDDSVDSTGDGGAALA
PGHLGGLVLENSDSLQ |
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| Predicted Disorder Regions | 3 disordered segments; (1-55), (79-85), (104-109) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Bisaillon R, Wilhelm BT, Krosl J, Sauvageau G. C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein. Blood. 2011 Oct 27;118(17):4682-9. doi: 10.1182/blood-2011-05-354076. Epub 2011 Sep 7. PMID: 21900201. |
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