Primary Information |
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| BoMiProt ID | Bomi6402 |
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| Protein Name | Inosine-5'-monophosphate dehydrogenase 1/IMP dehydrogenase 1/
IMPD 1/IMPDH 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A0JNA3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001071309.1 |
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| Aminoacid Length | 514 |
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| Molecular Weight | 55424 |
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| FASTA Sequence |
Download |
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| Gene Name | IMPDH1 |
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| Gene ID | 504305 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Inosine-5'-monophosphate dehydrogenase (IMPDH) catalyzes the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP) |
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| Biochemical Properties | Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme involved in purine nucleotide biosynthesis. It is responsible for catalyzing the oxidation of inosine monophosphate (IMP) into xanthosine monophosphate (XMP). |
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| PTMs | Methylation,Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A0JNA3|IMDH1_BOVIN Inosine-5'-monophosphate dehydrogenase 1 OS=Bos taurus OX=9913 GN=IMPDH1 PE=2 SV=2
MADYLISGGTGYVPEDGLTAQQLFANADGLTYNDFLILPGFIDFTADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKIRHGFSGIPITETGTMGSKLVGIVTS*160RDIDFLAEKDHTTLLSEVMT
PRNELVVAPAGVTLKEANEILQRSKKGKLPIVNDRDELVAIIARTDLKKNRDYPLASKDS
HKQLLCGAAVGTREDDKYRLDLLTQAGADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
VIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | 5F02, significantly inhibits IMPDH activity in a dose-dependent manner. |
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| Bibliography | 1.Wei Y, Kuzmič P, Yu R, Modi G, Hedstrom L. Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics. Biochemistry. 2016 Sep 20;55(37):5279-88. doi: 10.1021/acs.biochem.6b00265. Epub 2016 Sep 2. PMID: 27541177; PMCID: PMC5524190. 2.Anthony S, Peterson JR, Ji Y. Use of Inosine Monophosphate Dehydrogenase Activity Assay to Determine the Specificity of PARP-1 Inhibitors. Methods Mol Biol. 2017;1608:337-342. doi: 10.1007/978-1-4939-6993-7_22. PMID: 28695520. |
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