Primary Information |
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| BoMiProt ID | Bomi7046 |
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| Protein Name | Methionine aminopeptidase 2/MAP 2/MetAP 2/Initiation factor 2-associated 67 kDa glycoprotein/p67/p67eIF2/Peptidase M |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZC89 |
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| Milk Fraction | whey |
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| Ref Sequence ID | NP_001035583.1 |
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| Aminoacid Length | 477 |
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| Molecular Weight | 52812 |
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| FASTA Sequence |
Download |
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| Gene Name | METAP2 |
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| Gene ID | 404150 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It removes the N-terminal methionine from nascent proteins during translation. |
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| Biochemical Properties | The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged |
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| PTMs | Glycosylation, Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3ZC89|MAP2_BOVIN Methionine aminopeptidase 2 OS=Bos taurus OX=9913 GN=METAP2 PE=2 SV=1
MAGVEEAASCGSHLNGDLDPDEREEGAASTAEEAAKKKKRKKKKS*45KGAATGQQEPDKEAG
AS*62*62VDEVTRQLERQALEEKEKDDDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPIC
DLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRK
YVMSWIKPGMTMIEICEKMEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTV
LQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVG
EAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVY
AIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLD
RLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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| Predicted Disorder Regions | (1-120) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | O-glycosylation is required for EIF2S1 binding |
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| Bibliography | Goya Grocin, A., Kallemeijn, W. W., & Tate, E. W. (2021). Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity. Trends in pharmacological sciences, 42(10), 870–882. https://doi.org/10.1016/j.tips.2021.07.004 |
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