Primary Information |
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| BoMiProt ID | Bomi7445 |
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| Protein Name | Neurogranin/B-50 immunoreactive C-kinase substrate/BICKS/p17 |
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| Organism | Bos taurus |
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| Uniprot ID | P35722 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001106784.1 |
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| Aminoacid Length | 78 |
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| Molecular Weight | 7549 |
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| FASTA Sequence |
Download |
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| Gene Name | NRGN |
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| Gene ID | 616955 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Neurogranin (Ng) is a neural-specific postsynaptic protein that is highly enriched in dendrites and role in synaptic activity.promotes synaptogenesis. |
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| PTMs | Acetylation, Citrullination, Methylation, Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P35722|NEUG_BOVIN Neurogranin OS=Bos taurus OX=9913 GN=NRGN PE=1 SV=3
MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQAS*36FRGHMARKKIKSGERGRKGPGPGG
PGGAGGARGGAGGGPSGD
|
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| Predicted Disorder Regions | 1 disordered segment; (1-78) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions |
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| Bibliography | Xiang Y, Xin J, Le W, Yang Y. Neurogranin: A Potential Biomarker of Neurological and Mental Diseases. Front Aging Neurosci. 2020 Oct 6;12:584743. doi: 10.3389/fnagi.2020.584743. PMID: 33132903; PMCID: PMC7573493. |
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