Primary Information |
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| BoMiProt ID | Bomi7535 |
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| Protein Name | N-myc-interactor/N-myc and STAT interactor |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZCL3 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_001030270.1 |
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| Aminoacid Length | 309 |
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| Molecular Weight | 35395 |
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| FASTA Sequence |
Download |
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| Gene Name | NMI |
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| Gene ID | 511280 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | N-myc interactor (NMI), a member of the oncogene Myc family, has been reported to be closely related to the development of cancer. |
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| PTMs | Isopeptide bond formation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-90, 307-309 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Ubiquitination at 'Lys-63' by TRIM21 promotes interaction with IFI35 and inhibits virus-triggered type I IFN-beta production. |
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| Additional Comments | the downregulation of NMI plays an important role in the progression of cervical cancer, and may served as a novel therapeutic target for cervical cancer. |
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| Bibliography | 1.Wu S, Li X, Chai H, Feng L, Li W, Li H. Downregulation of N-myc Interactor Promotes Cervical Cancer Cells Growth by Activating Stat3 Signaling. Cell Biochem Biophys. 2021 Mar;79(1):103-111. doi: 10.1007/s12013-020-00943-0. Epub 2020 Oct 27. PMID: 33106998. |
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