Primary Information |
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| BoMiProt ID | Bomi8034 |
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| Protein Name | Pikachurin |
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| Organism | Bos taurus |
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| Uniprot ID | A3KN33 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001076947.1 |
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| Aminoacid Length | 1018 |
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| Molecular Weight | 111405 |
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| FASTA Sequence |
Download |
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| Gene Name | EGFLAM |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Pikachurin interactions with α-dystroglycan and its localization at the photoreceptor ribbon synapse require normal glycosylation of α-dystroglycan.Pikachurin protein is also required for increase of cone electroretinogram B-Wave during light adaptation. |
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| Biochemical Properties | . In the vertebrate retina, two forms of pikachurin have been detected: the full-length form (110kd) and the post-translational cleaved N-terminal fragment (60kd)[27]. The latter is involved in synaptic connection, bridging presynaptic and postsynaptic components |
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| Significance in milk | Photoreception |
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| PTMs | O-glycosylated; contains chondroitin sulfate and heparan sulfate. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A3KN33|EGFLA_BOVIN Pikachurin OS=Bos taurus OX=9913 GN=EGFLAM PE=2 SV=1
MDLIRGVLLRLLLLASSLGPGAAPLRSALRKQGKVGPPLDIILDALN*47CSAFSIQWKMPRH
PPSPIMGYTVFYSEVGIDKSLQERSYGVPPGLDTPTSGRLDHQMIFEEVIGDLKPGTEYR
VSMAAYSQTGKGRLSSPQHVTTLPQDSCLPPTAPQQPHVIVVSDSEVALSWKPGESEGSS
PIQYYSVEFTRPDFDKSWTSIREQIQMDSMVIKGLDPDTNYQFAVRAVNPHGSSPRSQPS
STIRTARPEESGSGRYGPHYATDTEAGEDDDTFEDDLDLDISFEEVKPLPAIKEGNKKFF
VESKMAPRPNPMTVSRLVPPTPASLPTTAVAPQPTPVDRKGKHGVAVMPRLFDTSCDETV
CSADSFCVSDYTWGGSRCHCNLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQI
TLEFRAEAEDGLLLYCGENEHGRGDFMSLAVIRRSLQFRFNCGTGVAIIVSETKIKLGGW
HTVTLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGF
QGCVQALTVNGKRLDLRPWPLGKALSGADVGECSSGICDEASCINGGTCMASKADSYICL
CPLGFRGRHCEDAFTLTIPQFKESLRSYAATPWPLEPRHYLSFMEFEVTFRPDSEDGVLL
YSYDTGSKDFLSINMAGGHVEFRFDCGSGTGVLRSEEPLTLGHWHELCVSRTAKNGILQV
DKQKAVEGMAEGGFTQIKCNSDIFIGGVPNYDDVKKNSGILKPFSGSIQKIILNDRTIHV
KHDFTWGVNVENAAHPCVGSPCAHGGSCRPRKEGYECDCPLGFEGLHCQKAITEAIEIPQ
FIGRSYLTYDNPDILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDG
ALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLN
INGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Pikachurin Is Partially Involved in the Synaptic Connection Between Donor and Host Cells in Late-Stage rd1 Mice Following Conspecific Photoreceptor Transplantation |
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| Bibliography | 1.Liang, Chen; Chen, YingYing; Jiang, XiaoShuang; Zou, Ming; Yang, Zhen; Li, HuiFang; Peng, LanYa (2020). Pikachurin is partially involved in the synaptic connection between donor and host cells in late-stage rd1 mice following conspecific photoreceptor transplantation. Stem Cells and Development, (), scd.2019.0268–. doi:10.1089/scd.2019.0268. 2.Nagaya M, Ueno S, Kominami T, Nakanishi A, Koyasu T, Kondo M, Furukawa T, Terasaki H. Pikachurin Protein Required for Increase of Cone Electroretinogram B-Wave during Light Adaptation. PLoS One. 2015 Jun 19;10(6):e0128921. doi: 10.1371/journal.pone.0128921. PMID: 26091521; PMCID: PMC4475018. |
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