Primary Information |
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| BoMiProt ID | Bomi8052 |
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| Protein Name | Plakophilin-1/Band-6 protein |
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| Organism | Bos taurus |
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| Uniprot ID | Q28161 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776570.1 |
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| Aminoacid Length | 727 |
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| Molecular Weight | 80180 |
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| FASTA Sequence |
Download |
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| Gene Name | PKP1 |
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| Gene ID | 281405 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Plakophilin 1 is a desmosomal plaque protein and a member of the armadillo family of structural and signalling proteins. |
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| PTMs | Phosphorylation at Serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q28161|PKP1_BOVIN Plakophilin-1 OS=Bos taurus OX=9913 GN=PKP1 PE=2 SV=1
MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQVMMTVKRQKSKSSQSS
TLSHSNRGSMYDGLADSYNNYGTSSRSSFYSKFQAGSGSWGYPIYNGTLKREADNRRFSS
YS*122QMESWGRQYPRGGCTAAGAGS*143DICFMQKIKASRSEPDLYCDPRGTLRKGTLGGKGHKT
TQNRYSFYSTCSGQKAVKKYPGRPPSCTSRQDPVCVPPTSCTKDLSFSHSRASSKICSED
IECSGLTIPKAVQYLSSQDEKCQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP
NQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGSTEIQKQLTGLLWNLSS
TDELKEELIAEALPVLADRVIIPFSGWCDGNSNLSREPVDPEVFFNATGCLRNLSSADVG
RQTMRNYTGLIDSLMAYVQNCVAANRCDDKSVENCMCVLHNLSYRLDAEVPTRYRQLEYN
ARNAYTDKSSTGCFSNKSDRMTNNNYDCPLPEEEPNPKGSSWLYHSDAVRTYLNLMGKSK
KDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPHIARLLQSGNSDVVRSGASLLS
NMSRHPALHRVMGTQVFPEVTRLLTSHTGNTSNSEDILASACYTVRNLMASLPGMAKQHF
SSSMVNNIINLCRSSTSPKAAEAARLLLSDMWSSRELQGLLRQQGFDRSMLGTLAGANSL
RNFTSRF
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| Predicted Disorder Regions | 1-6, 23-67, 170-177, 200-206, 506-511 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | PKP1 overexpression increased cell proliferation, cell survival, and in vivo xenograft engraftment. |
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| Bibliography | 1.South AP. Plakophilin 1: an important stabilizer of desmosomes. Clin Exp Dermatol. 2004 Mar;29(2):161-7. doi: 10.1111/j.1365-2230.2004.01467.x. PMID: 14987275. 2.Martin-Padron J, Boyero L, Rodriguez MI, Andrades A, Díaz-Cano I, Peinado P, Baliñas-Gavira C, Alvarez-Perez JC, Coira IF, Fárez-Vidal ME, Medina PP. Plakophilin 1 enhances MYC translation, promoting squamous cell lung cancer. Oncogene. 2020 Aug;39(32):5479-5493. doi: 10.1038/s41388-019-1129-3. Epub 2019 Dec 10. Erratum in: Oncogene. 2020 Jan 13;: PMID: 31822797. |
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