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Primary Information | |
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| BoMiProt ID | Bomi8416 |
| Protein Name | Protein S100-A1/S-100 protein alpha chain/S-100 protein subunit alpha/S100 calcium-binding protein A1 |
| Organism | Bos taurus |
| Uniprot ID | P02639 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_001092512.1 |
| Aminoacid Length | 94 |
| Molecular Weight | 10518 |
| FASTA Sequence | Download |
| Gene Name | S100A1 |
| Gene ID | 528735 |
| Protein Existence Status | Reviewed |
Secondary Information | |
| Protein Function | Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes. |
| Significance in milk | major constituents of the bovine teat canal lining |
| PTMs | Glutathionylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | NA |
| SCOP | Class : All alpha proteins Fold : Pair of EF Hands-like Superfamily : EF-hand Family : S100 proteins Domain Name : 2JPT A:1-93 |
| CATH | Matched CATH superfamily 1.10.238.10 |
| Predicted Disorder Regions | 1-5, 20-32, 47-53, 91-94 |
| DisProt Annotation | |
| TM Helix Prediction | no TM helices |
| Significance of PTMs | glutathionylation increases affinity to calcium about 10-fold. |
| PDB ID | 2JPT, |
| Bibliography | Kuwano, R., Maeda, T., Usui, H., Araki, K., Yamakuni, T., Ohshima, Y., Kurihara, T., & Takahashi, Y. (1986). Molecular cloning of cDNA of S100 alpha subunit mRNA. FEBS letters, 202(1), 97–101. https://doi.org/10.1016/0014-5793(86)80656-1 |