Primary Information |
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| BoMiProt ID | Bomi8445 |
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| Protein Name | Protein tyrosine phosphatase domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A7E379 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 796 |
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| Molecular Weight | 89386 |
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| FASTA Sequence |
Download |
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| Gene Name | PTPDC1 |
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| Gene ID | 519311 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | is a homologue of the mitotic phosphatase CDC14 that associates with PLK1 and has been localized to centrosomes .play roles inciliary length determination, cilia/podocyte formation and maintenance. |
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| Biochemical Properties | has calmodulin-binding IQ motif and ubiquitin-like (UBL) domain.three additional C-terminal domains: a helical solenoid segment coupled to a short Cx2Cx20Cx2C Zn2+-binding module (Z), and a novel 120-amino-acid α+β domain. |
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| PTMs | phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A7E379|PTPC1_BOVIN Protein tyrosine phosphatase domain-containing protein 1 OS=Bos taurus OX=9913 GN=PTPDC1 PE=2 SV=2
MQDPPRRLSAVPFLSSFFEGRRHSASDPILRLQQGRRSSAAKVLSSSSLQVMVAMSSVSC
AERNPTCPERKRNSGRPTPKYTKVGERLRHVIPGHVACSMACGGKACKYENAARWSEQEQ
AVKGIYSSWVTDNILAMARPSTEVLEKFCIIEQFRSHGIKSIINLQRPGEHASCGNPLEQ
ESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGR
TGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLIPLRNIFSCCDP
KAHAVTLAQYLIRQRHLLHGYEARLLKHIPKIIHLVCKLLLDLAENRPVVTEVADIPGLS
AEIEKTVSEMITRQLDKELLRHDSDASDSFTPTAVVMDFENQDVVLSSEQELDPLWKRRN
VECLQPLAHLKRQLS*435YS*437DSDLKRAESLLEQGRTPWTVPAQALLCHNPRQQKHISRCYSPQ
SPQLDLNKETLVRNTFSFWNHTKFGVPEGLKDDGSLIFHRTSIPKEVQRSRTFSSGISDS
YNPGEPVTPNSANIPKGPNSSQQKVYHCECESHGGCGPSSVAEDGETCRRPVDCGSSPKA
QFLGNETQNSKYLSEVAAHMPLQSELSVEARRILAAKALANLNEIAEKEEVKKKVEMWQK
ELNSRDGAWERICGEKDPFILCSLMWSWVEQLKEPVITKEDMDMLVDRCADASEALFLLE
KGQQQTILCVLHCIVSLQTIPADVEEAVLARAIKAFTKVNFDSENGPIVYNTLKKIFKRT
LEEKRKMTKDNPEPGI
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ. Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19. doi: 10.1091/mbc.E10-07-0596. Epub 2011 Feb 2. PMID: 21289087; PMCID: PMC3069013. |
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