Primary Information |
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| BoMiProt ID | Bomi8584 |
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| Protein Name | Rab-like protein 6/GTP-binding protein Parf/Rab-like protein 1/RBEL1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q08DA0 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence ID | NP_001070285.1 |
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| Aminoacid Length | 701 |
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| Molecular Weight | 77097 |
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| FASTA Sequence |
Download |
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| Gene Name | RABL6/PARF |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Rab-like protein 6 may be involved in enhancement of cellular proliferation and reduction of growth inhibitory activity of CDKN2A |
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| Biochemical Properties | RABL6 is a member of the Ras subfamily which are made up of small GTPases. |
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| PTMs | Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q08DA0|RABL6_BOVIN Rab-like protein 6 OS=Bos taurus OX=9913 GN=RABL6 PE=2 SV=1
MFSALKKLVGSEQAPGRDRNIPAGLQSMNQALQRRFAKGVQYNMKIVIRGDRNTGKTALW
HRLQGKKFVEEYIPTQEIQVTSIHWSYKTTDDVVKVEVWDVVDKGKCKKRGDGLKMENDP
QEAESEMALDAEFLDVYKNCNGVVMMFDITKQWTFNYILRELPKVPTHVPVCVLGNYRDM
GEHRVILPDDVRDVLDHLDRPPGSSYFRYAESSMKNSFGLKYLHRFFNIPFLQLQRETLL
RQLETNQLDIDATLEELSVQQETEDQNYDIFLEMMEARSRGHASPLTTSGQSPSSGSQSP
VVPPSTVSTGSSSPSTPQPVLQPPLQAPPAPPAPAEAPPLPAAPPRRSIIARLFGSTPAT
EAAPPPPEPTPAAEASQKVQNVEDFVPEDSLDGS*394FLEDTVPAKDEKRLGARGPQDS*416DS*418DR
ETQAGNPMVAGFQDDVDLEDKPPSRPLPPTGPVPSEDITLS*461S*462EEEAEEGAGHPKAAVLAP
QKCPEPETRRSSTKALGPPRDAAPRAAKPRPEGPSGKLEEGTDKPVSSESDAEGPIAAQM
LSFVMDDPDFES*552DSDAQRRAGEFPVREDLS*570DLT*573DEDAGPVQPPAPPKPLAPSFRLKDDSD
LFGLGLEEPGREDS*614S*615EQDKEGRPPAKEKKKKKKKGREEEDKAAKKRSKHKKSRERADDKG
RDERRRRPRGPQRTALDELEAFLGGGAPSGPLRGGGDYEAL
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| Predicted Disorder Regions | 12-21, 263-339, 368-508, 540-600, 621-660 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | knocking down of RABL6 in osteosarcoma cells also impaired cell colony formation and proliferation |
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| Bibliography | 1.Feng, Y., Yan, S., Huang, Y. et al. High expression of RABL6 promotes cell proliferation and predicts poor prognosis in esophageal squamous cell carcinoma. BMC Cancer 20, 602 (2020). https://doi.org/10.1186/s12885-020-07068-w 2.Tang, H., Ji, F., Sun, J., Xie, Y., Xu, Y., & Yue, H. (2016). RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1. Molecular medicine reports, 13(2), 1275–1280. https://doi.org/10.3892/mmr.2015.4670 |
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