Primary Information
BoMiProt ID	Bomi8742
Protein Name	Retrotransposon-like protein 1/Paternally expressed gene 11 protein homolog/Retrotransposon-derived protein PEG11
Organism	Bos taurus
Uniprot ID	Q52QI2
Milk Fraction	Whey
Ref Sequence ID	NP_001181949.1
Aminoacid Length	1331
Molecular Weight	151448
FASTA Sequence	Download
Gene Name	RTL1/PEG11
Gene ID	606737
Protein Existence Status	reviewed
Secondary Information
Protein Function	is expressed as a full-length protein in skeletal muscle from Callipyge sheep.
Biochemical Properties	The region of PEG11 corresponding with that encoding antisense mir-431 is associated with propensity for coiled coil formation. Whilst coiled coils are a general feature of the PEG11 protein sequence, the region corresponding to that encoded by antisense mir-431 is highly conserved in its propensity for coiled coil formation suggesting an important function possibly involving protein-protein interactions.
PTMs	Lipolyation, Myristoylation, Phosphorylation at Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1-140, 560-600, 998-1028, 1324-1327
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy
Bibliography	1.Xu X, Ectors F, Davis EE, Pirottin D, Cheng H, Farnir F, Hadfield T, Cockett N, Charlier C, Georges M, Takeda H. Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy. PLoS One. 2015 Oct 16;10(10):e0140594. doi: 10.1371/journal.pone.0140594. PMID: 26474044; PMCID: PMC4608697. 2.Byrne K, Colgrave ML, Vuocolo T, Pearson R, Bidwell CA, Cockett NE, Lynn DJ, Fleming-Waddell JN, Tellam RL. The imprinted retrotransposon-like gene PEG11 (RTL1) is expressed as a full-length protein in skeletal muscle from Callipyge sheep. PLoS One. 2010 Jan 8;5(1):e8638. doi: 10.1371/journal.pone.0008638. PMID: 20072617; PMCID: PMC2799525.