Primary Information |
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| BoMiProt ID | Bomi9978 |
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| Protein Name | Translation initiation factor IF-3, mitochondrial/
IF-3(Mt)/
IF-3Mt/IF3(mt)/IF3mt |
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| Organism | Bos taurus |
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| Uniprot ID | Q32KZ1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001033155.1 |
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| Aminoacid Length | 273 |
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| Molecular Weight | 30619 |
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| FASTA Sequence |
Download |
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| Gene Name | MTIF3 |
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| Gene ID | 509987 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | plays an active role in the initiation of translation in mammalian mitochondria |
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| Biochemical Properties | Mitochondrial translational initiation factor 3 (IF3(mt)) is a 29 kDa protein that has N- and C-terminal domains, homologous to prokaryotic IF3, connected by a linker region. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| na |
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| Predicted Disorder Regions | 31-69, 138-150, 243-273 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Mutation of residues 247 and 248 in the C-terminal extension abolished the ability of IF3(mt) to reduce the level of binding of fMet-tRNA to the ribosome in the absence of mRNA. |
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| Bibliography | Christian BE, Spremulli LL. Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria. Biochemistry. 2009 Apr 21;48(15):3269-78. doi: 10.1021/bi8023493. PMID: 19239245; PMCID: PMC3711378. |
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