Primary Information
BoMiProt ID	Bomi10478
Protein Name	Vesicle-associated membrane protein 1/Synaptobrevin-1
Organism	Bos taurus
Uniprot ID	Q0V7N0
Milk Fraction	Whey
Ref Sequence ID	NP_001069098.2
Aminoacid Length	118
Molecular Weight	12860
FASTA Sequence	Download
Gene Name	VAMP1/SYB1
Gene ID	513621
Protein Existence Status	reviewed
Secondary Information
Protein Function	involved in the synaptic vesicle cycle, exocytosis, at the presynaptic nerve terminal. Neuronal VAMPs are anchored in the vesicle membrane by their C-terminal domain.
Biochemical Properties	118-aa long.a cytoplasmic N-terminal domain rich in prolines and glycines, followed by a highly conserved hydrophilic region, a transmembrane domain, and a C-terminal intravesicular domain.
PTMs	phosphorylation
Linking IDs	Bomi10478
Bibliography	Hu K, Carroll J, Fedorovich S, Rickman C, Sukhodub A, Davletov B. Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion. Nature. 2002 Feb 7;415(6872):646-50. doi: 10.1038/415646a. PMID: 11832947.
Protein Function	involved in the synaptic vesicle cycle, exocytosis, at the presynaptic nerve terminal. Neuronal VAMPs are anchored in the vesicle membrane by their C-terminal domain.
Biochemical Properties	118-aa long.a cytoplasmic N-terminal domain rich in prolines and glycines, followed by a highly conserved hydrophilic region, a transmembrane domain, and a C-terminal intravesicular domain.
PTMs	phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q0V7N0|VAMP1_BOVIN Vesicle-associated membrane protein 1 OS=Bos taurus OX=9913 GN=VAMP1 PE=3 SV=2 MSAPAQPPTEGAEGAAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIMRVNVDKVLERDQ KLS*63ELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFA
Predicted Disorder Regions	2 disordered segments; (1-42), (69-83)
DisProt Annotation
TM Helix Prediction	1TMH; (99-117)
Linking IDs
Bibliography	Hu K, Carroll J, Fedorovich S, Rickman C, Sukhodub A, Davletov B. Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion. Nature. 2002 Feb 7;415(6872):646-50. doi: 10.1038/415646a. PMID: 11832947.