Primary Information |
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| BoMiProt ID | Bomi8460 |
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| Protein Name | Protein-L-isoaspartate(D-aspartate) O-methyltransferase/L-isoaspartyl protein carboxyl methyltransferase/Protein-beta-aspartate methyltransferase |
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| Organism | Bos taurus |
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| Uniprot ID | P15246 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001073085.1 |
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| Aminoacid Length | 227 |
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| Molecular Weight | 24565 |
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| FASTA Sequence |
Download |
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| Gene Name | PCMT1 |
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| Gene ID | 613854 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | semitendinosus |
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| Protein Function | Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is identified as an Mst1-interacting protein.PCMT1 as a novel inhibitor of Mst1 activation in cardiomyocytes and suggest that targeting PCMT1 may prevent myocardial apoptosis through inhibition of Mst1. |
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| PTMs | N-acetylation at Alanine |
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| Additional Comments | deletion of PCMT1 significantly alters red blood cell metabolism in a healthy state, but does not impair the circulatory lifespan of red blood cells. |
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| Linking IDs | Bomi8460 |
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| Bibliography | 1.D'Alessandro A, Hay A, Dzieciatkowska M, Brown BC, Morrison EJ, Hansen KC, Zimring JC. Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. Haematologica. 2021 Oct 1;106(10):2726-2739. doi: 10.3324/haematol.2020.266676. PMID: 33054131; PMCID: PMC8485689. 2.Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3. PMID: 23647599; PMCID: PMC3788851. |
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| Presence in other biological fluids/tissue/cells | semitendinosus |
|---|
| Protein Function | Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) is identified as an Mst1-interacting protein.PCMT1 as a novel inhibitor of Mst1 activation in cardiomyocytes and suggest that targeting PCMT1 may prevent myocardial apoptosis through inhibition of Mst1. |
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| PTMs | N-acetylation at Alanine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | deletion of PCMT1 significantly alters red blood cell metabolism in a healthy state, but does not impair the circulatory lifespan of red blood cells. |
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| Linking IDs | |
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| Bibliography | 1.D'Alessandro A, Hay A, Dzieciatkowska M, Brown BC, Morrison EJ, Hansen KC, Zimring JC. Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells. Haematologica. 2021 Oct 1;106(10):2726-2739. doi: 10.3324/haematol.2020.266676. PMID: 33054131; PMCID: PMC8485689. 2.Yan G, Qin Q, Yi B, Chuprun K, Sun H, Huang S, Sun J. Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol. 2013 Oct 9;168(4):3291-9. doi: 10.1016/j.ijcard.2013.04.045. Epub 2013 May 3. PMID: 23647599; PMCID: PMC3788851. |
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